Research Paper Volume 13, Issue 19 pp 23182—23192

Decreased gray matter volume and increased white matter volume in patients with neovascular age-related macular degeneration: a voxel-based morphometry study

Correlation between the mean GMV and severity of HADS in different brain areas. Notes: (A) The GMV value of the right inferior frontal gyrus of the nAMD group portrayed a non-linear correlation with the severity of HADS (r=-0.6629, P=0.0027). (B) The GMV value of the left middle frontal gyrus of the nAMD group portrayed a non-linear correlation with the severity of HADS(r=-0.9451, pC) The GMV value of the left anterior cingulate and paracingulate gyrus of the nAMD group portrayed a non-linear correlation with the severity of HADS(r=-0.6183, p=0.0062). Abbreviations: GMV, gray matter volume; HADS, hospital anxiety and depression scale; nAMD, neovascular age-related macular degeneration.

Figure 3. Correlation between the mean GMV and severity of HADS in different brain areas. Notes: (A) The GMV value of the right inferior frontal gyrus of the nAMD group portrayed a non-linear correlation with the severity of HADS (r=-0.6629, P=0.0027). (B) The GMV value of the left middle frontal gyrus of the nAMD group portrayed a non-linear correlation with the severity of HADS(r=-0.9451, p<0.0001). (C) The GMV value of the left anterior cingulate and paracingulate gyrus of the nAMD group portrayed a non-linear correlation with the severity of HADS(r=-0.6183, p=0.0062). Abbreviations: GMV, gray matter volume; HADS, hospital anxiety and depression scale; nAMD, neovascular age-related macular degeneration.