Research Paper Volume 13, Issue 19 pp 23233—23244

Long non-coding RNA CRNDE as potential biomarkers facilitate inflammation and apoptosis in alcoholic liver disease

Differentially lncRNAs in alcoholic liver disease. (A) The flowchart of the integrated analysis and functional validation. In silico bioinformatics data analysis pipeline consists of curation of 2 publicly available datasets, data preprocessing, and integrated analysis, dataset validation, GSEA, and in vitro functional validation. (B) Heatmap of differentially expressed lncRNAs in GSE28619 dataset; each column represents a sample and each row represents a specific lncRNA. |log2FC| >1 and adjusted PC) Heatmap of differentially expressed lncRNAs in GSE143318 dataset; each column represents a sample and each row represents a specific lncRNA. |log2FC| >1 and adjusted P

Figure 1. Differentially lncRNAs in alcoholic liver disease. (A) The flowchart of the integrated analysis and functional validation. In silico bioinformatics data analysis pipeline consists of curation of 2 publicly available datasets, data preprocessing, and integrated analysis, dataset validation, GSEA, and in vitro functional validation. (B) Heatmap of differentially expressed lncRNAs in GSE28619 dataset; each column represents a sample and each row represents a specific lncRNA. |log2FC| >1 and adjusted P<0.05. Red indicates upregulation and green indicates downregulation of expression. (C) Heatmap of differentially expressed lncRNAs in GSE143318 dataset; each column represents a sample and each row represents a specific lncRNA. |log2FC| >1 and adjusted P<0.05. Red indicates upregulation and green indicates downregulation of expression.