Research Paper Volume 13, Issue 19 pp 23245—23261

Identification of potential target genes of non-small cell lung cancer in response to resveratrol treatment by bioinformatics analysis

The expression of hub genes in Oncomine™. Six LUAD and four LUSC datasets were selected and the expression of the hub genes was compared across the ten datasets. Normal tissues were chosen as control. Blue colors represented under-expression, and red colors referred to over-expression of hub genes. Colors were shown in blue or red from light to dark according to the quantity of expression (from low to high). ANPEP, CD69, ITGAL, PTPRC, ITGA1, CCL2, and PECAM1 were considered to down-regulate in LUSC and LUAD datasets (P P P = 0.119).

Figure 5. The expression of hub genes in Oncomine™. Six LUAD and four LUSC datasets were selected and the expression of the hub genes was compared across the ten datasets. Normal tissues were chosen as control. Blue colors represented under-expression, and red colors referred to over-expression of hub genes. Colors were shown in blue or red from light to dark according to the quantity of expression (from low to high). ANPEP, CD69, ITGAL, PTPRC, ITGA1, CCL2, and PECAM1 were considered to down-regulate in LUSC and LUAD datasets (P < 0.05). EGFR was up-regulated in LUSC and LUAD datasets (P < 0.05). There was no significant different on SOX2 expression between tumor and normal samples (P = 0.119).