Research Paper Volume 13, Issue 19 pp 22710—22731

Neurovascular dysfunction and neuroinflammation in a Cockayne syndrome mouse model

Impaired angiogenesis does not increase astro or microgliosis in adult CX mice. (A) Axitinib treatment does not alter astrogliosis in adult CX brain cortex nor corpus callosum, as measured by GFAP staining. (B) Axitinib treatment decreases microgliosis in the cortex, but not the corpus callosum of CX mice. Data are presented as mean ± SE. Two way Anova followed by Tukey’s post hoc test, n = 4. P values of less than or equal to 0.05, 0.01, 0.001 and 0.0001 are indicated by asterisks (*) when comparing within the same treatment group and by the pound sign (#) when comparing between treatment groups.

Figure 6. Impaired angiogenesis does not increase astro or microgliosis in adult CX mice. (A) Axitinib treatment does not alter astrogliosis in adult CX brain cortex nor corpus callosum, as measured by GFAP staining. (B) Axitinib treatment decreases microgliosis in the cortex, but not the corpus callosum of CX mice. Data are presented as mean ± SE. Two way Anova followed by Tukey’s post hoc test, n = 4. P values of less than or equal to 0.05, 0.01, 0.001 and 0.0001 are indicated by asterisks (*) when comparing within the same treatment group and by the pound sign (#) when comparing between treatment groups.