Research Paper Volume 13, Issue 19 pp 22732—22751

The central role of the glutamate metabolism in long-term antiretroviral treated HIV-infected individuals with metabolic syndrome

Differing metabolites and pathways found between PLWH and PLWH with MetS. (A) Doughnut charts of metabolite proportions for each super pathway for all detected metabolites (left) and metabolites with differential abundance between PLWH and PLWH with MetS (LIMMA, FDR n = 69). (B) Metabolites contribution to the flow of top 13 pathways represented as Sankey Plot. (C) Cytoscape network of top 13 pathways and associated enriched metabolites.

Figure 1. Differing metabolites and pathways found between PLWH and PLWH with MetS. (A) Doughnut charts of metabolite proportions for each super pathway for all detected metabolites (left) and metabolites with differential abundance between PLWH and PLWH with MetS (LIMMA, FDR < 0.1, n = 69). (B) Metabolites contribution to the flow of top 13 pathways represented as Sankey Plot. (C) Cytoscape network of top 13 pathways and associated enriched metabolites.