Research Paper Volume 13, Issue 19 pp 22752—22771

Exposure to ionizing radiation disrupts normal epigenetic aging in Japanese medaka

Construction of an epigenetic age predictor in medaka. (A) Conceptual diagram of the RRBS experiment. (B) Description and performance metrics of the medaka epigenetic clock. (C) Performance of the epigenetic clock on the training set (n=37) and (D) test set (n=10). (E) Heat map of the methylation of the 10 clock cytosines. Age is specified by color intensity (2-month: light gray to 14-month: black).

Figure 2. Construction of an epigenetic age predictor in medaka. (A) Conceptual diagram of the RRBS experiment. (B) Description and performance metrics of the medaka epigenetic clock. (C) Performance of the epigenetic clock on the training set (n=37) and (D) test set (n=10). (E) Heat map of the methylation of the 10 clock cytosines. Age is specified by color intensity (2-month: light gray to 14-month: black).