Research Paper Volume 13, Issue 19 pp 22752—22771

Exposure to ionizing radiation disrupts normal epigenetic aging in Japanese medaka

Effect of ionizing radiation on age-associated DNA methylation. Epigenetic age estimates for fish exposed to 7-weeks of ionizing radiation at various dose rates (0, 5, 50, and 500 mGy/day) as predicted by (A) a linear model, (B) PCA, and (C) elastic net age predictors. (D) Percent of reads with discordant methylation across exposure groups.

Figure 3. Effect of ionizing radiation on age-associated DNA methylation. Epigenetic age estimates for fish exposed to 7-weeks of ionizing radiation at various dose rates (0, 5, 50, and 500 mGy/day) as predicted by (A) a linear model, (B) PCA, and (C) elastic net age predictors. (D) Percent of reads with discordant methylation across exposure groups.