Research Paper Volume 13, Issue 19 pp 22752—22771

Exposure to ionizing radiation disrupts normal epigenetic aging in Japanese medaka

Interactive effects of exposure to ionizing radiation and age on the medaka DNA methylome. (A) Diagram of a hypothetical continuum of cytosines with cytosines affected strongly by age on one end and those which are highly environmentally responsive on the other. (B) Distributions of cytosines affected by IR exposure along the continuum of association with chronological age. Background represents the number of overlapping CpGs in the two datasets (age and radiation exposure).

Figure 4. Interactive effects of exposure to ionizing radiation and age on the medaka DNA methylome. (A) Diagram of a hypothetical continuum of cytosines with cytosines affected strongly by age on one end and those which are highly environmentally responsive on the other. (B) Distributions of cytosines affected by IR exposure along the continuum of association with chronological age. Background represents the number of overlapping CpGs in the two datasets (age and radiation exposure).