Research Paper Advance Articles

Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner

Over-expression of Nmnat2 reduces Aβ in the medium of N2a/APPswe cells. The medium of N2a/APPswe cells transfected with Flag-Nmnat2 (Nmnat2) or the empty vector for forty eight hours was measured for Aβ1-40 and Aβ1-42 by using ELISA and quantitative analysis (A–C). The data were representative of at least three independent experiments and expressed as means ± S.D.. *P P

Figure 3. Over-expression of Nmnat2 reduces Aβ in the medium of N2a/APPswe cells. The medium of N2a/APPswe cells transfected with Flag-Nmnat2 (Nmnat2) or the empty vector for forty eight hours was measured for Aβ1-40 and Aβ1-42 by using ELISA and quantitative analysis (AC). The data were representative of at least three independent experiments and expressed as means ± S.D.. *P < 0.05, **P < 0.01 vs control.