Research Paper Volume 13, Issue 20 pp 23672—23688

Differences in and verification of genetic alterations in chemotherapy and immunotherapy for metastatic melanoma

Flowchart of screening signature genes and its Kaplan-Meier survival curve and receiver operating characteristic curve (ROC). (A) Flowchart of screening signature genes. Including volcano plot of differentially expressed genes (DEGs), DEGs’ PPI network and Lasso-COX fitting model. (B) DEGs immune cell infiltration analysis, Pearson correlation test of Anti-tumor and Pro-tumor suppression based on immune cell type enrichment scores. (C) Log-rank test for survival curves of signature genes. (D) ROC curve, area under curve (AUC), sensitivity, specificity and accuracy values of signature genes.

Figure 2. Flowchart of screening signature genes and its Kaplan-Meier survival curve and receiver operating characteristic curve (ROC). (A) Flowchart of screening signature genes. Including volcano plot of differentially expressed genes (DEGs), DEGs’ PPI network and Lasso-COX fitting model. (B) DEGs immune cell infiltration analysis, Pearson correlation test of Anti-tumor and Pro-tumor suppression based on immune cell type enrichment scores. (C) Log-rank test for survival curves of signature genes. (D) ROC curve, area under curve (AUC), sensitivity, specificity and accuracy values of signature genes.