Research Paper Volume 13, Issue 20 pp 23739—23756

Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer’s disease

Effects of loganin on anxiety and memory behavior. (A) Total distance traveled in the open field. (B) The percentage of time spent in the center of the open field. (C) The percentage of distanced traveled in the open arm of the elevated plus maze. (D) The percentage of time spent in the open arm of the elevated plus maze. (E) The escape latency. (F) Total distance traveled in probe trial of Morris water maze. (G) Average speed in the probe trial of Morris water maze. (H) The percentage of time spent in the target quadrant. (I) The percentage of distance traveled in the target quadrant. Data were expressed as mean ± SEM, *p **p

Figure 1. Effects of loganin on anxiety and memory behavior. (A) Total distance traveled in the open field. (B) The percentage of time spent in the center of the open field. (C) The percentage of distanced traveled in the open arm of the elevated plus maze. (D) The percentage of time spent in the open arm of the elevated plus maze. (E) The escape latency. (F) Total distance traveled in probe trial of Morris water maze. (G) Average speed in the probe trial of Morris water maze. (H) The percentage of time spent in the target quadrant. (I) The percentage of distance traveled in the target quadrant. Data were expressed as mean ± SEM, *p < 0.05, **p < 0.01, n = 10 - 15 for each group.