Rab7 silencing reversed hypoxia-induced decrease of cell migration and angiogenesis. (A) The migration of HMEC-1 cells was tested by transwell assay. (B) The angiogenesis of HMEC-1 cells was investigating by calculating the total length. (C, D) The MMP-2 activity in HMEC-1 cells was tested by Gelatin Zymography. *P<0.05, **P<0.01.