Research Paper Volume 13, Issue 20 pp 23769—23779

Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis

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Figure 3.

Rab7 silencing reversed hypoxia-induced decrease of cell migration and angiogenesis. (A) The migration of HMEC-1 cells was tested by transwell assay. (B) The angiogenesis of HMEC-1 cells was investigating by calculating the total length. (C, D) The MMP-2 activity in HMEC-1 cells was tested by Gelatin Zymography. *P<0.05, **P<0.01.