Research Paper Volume 13, Issue 20 pp 23769—23779

Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis

Rab7 silencing reversed hypoxia-induced decrease of MMP-2 activity via regulation of RECK, MMP-14 and Caveolin-1. (A) The protein levels of HIF-1α, MMP-14, Caveolin-1 and RECK in HMEC-1 cells were detected by western blot. (B–E) β-actin was used for quantification. *P**P

Figure 4. Rab7 silencing reversed hypoxia-induced decrease of MMP-2 activity via regulation of RECK, MMP-14 and Caveolin-1. (A) The protein levels of HIF-1α, MMP-14, Caveolin-1 and RECK in HMEC-1 cells were detected by western blot. (BE) β-actin was used for quantification. *P<0.05, **P<0.01.