Research Paper Volume 13, Issue 20 pp 23769—23779

Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis

Knockdown of Rab7 significantly alleviated the symptom of CKD in vivo. (A, B) Sirius red staining was used to detect the fibrosis in kidney tissues of mice. The level of CD34 in kidney tissues of mice was detected by IHC staining. (C) The protein levels of HIF-1α, Rab7, MMP-14 and RECK in kidney tissues of mice were detected by western blot. (D–G) β-actin was used for quantification. **P

Figure 6. Knockdown of Rab7 significantly alleviated the symptom of CKD in vivo. (A, B) Sirius red staining was used to detect the fibrosis in kidney tissues of mice. The level of CD34 in kidney tissues of mice was detected by IHC staining. (C) The protein levels of HIF-1α, Rab7, MMP-14 and RECK in kidney tissues of mice were detected by western blot. (DG) β-actin was used for quantification. **P<0.01.