Research Paper Volume 13, Issue 20 pp 23780—23795

Matairesinol exerts anti-inflammatory and antioxidant effects in sepsis-mediated brain injury by repressing the MAPK and NF-κB pathways through up-regulating AMPK

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Figure 3.

Mat alleviated CLP-induced acute brain injury in rats. A rat sepsis model was constructed using the CLP surgery, based on which rats were given oral doses of Mat at different concentrations (5 to 20 mg/kg) for 48 hours. (AC) Blood analysis was utilized to compare the concentrations of S100β, GFAP and NSE in the rat serum. (D) Brain edema was measured using wet-dry method. (E) Brain tissues were stained with H&E. (F) IHC was taken to calculate the Caspase-3-positive cell number. (G) TUNEL staining was performed to detect tissue apoptosis. **P < 0.01, ***P < 0.001 (vs. sham group). ns P > 0.05, +P < 0.05, ++P < 0.01, ++P < 0.001 (vs. CLP group).