**Figure 2.** **Physiological aging rates are associated with mortality.** (**A**) Age-matched mortality analysis: 265 deceased participants were randomly paired with age- Matched ± 0.5 years) living participants in the baseline SardiNIA study. We calculated the difference in the mean PAR measurements of the two groups, ΔPAR = PAR_{deceased} – PAR_{living} and the corresponding *p*-value from a one-sided, one-sample *t*-test for ΔPAR > 0.The age-matched grouping was performed 10000 times and ΔPAR and *p*-values were calculated for each of the 10000 comparisons. 77.4% of the age-matched comparisons produced significantly greater than zero ΔPAR values (*p* < 0.05) and the mean ΔPAR across all comparisons was 0.016. Nearly all comparisons (>99%) had ΔPAR > 0, which indicated that PAR_{deceased} > PAR_{living} on average. (**B**) Randomized, age-matched control comparisons produced a 5.2% frequency of significantly greater than zero (*p* < 0.05) ΔPAR values and the mean ΔPAR was 0.00. Consistent with random assignment, 50.8% of the ΔPAR values were greater than zero. (**C**) Lifespans for individuals were negatively correlated with PARs (r = −0.491).