Research Paper Volume 13, Issue 24 pp 25799—25845

DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival


Figure 9. The correlation between the abundance of tumor-infiltrating lymphocytes (TILs) and the methylation of ARHGAP30. (A) Heat map of the relationship between the abundance of TILs abundance and ARHGAP30 DNA methylation. (B1B39) Scatter plots showing the negative correlation between ARHGAP30 DNA methylation and TILs in the treatment of lung adenocarcinoma. Act_CD8, Activated CD8 T cell; Tcm_CD8, Central memory CD8 T cell; Tem_CD8, Effector memory CD8 T cell; Act_CD4, Activated CD4 T cell; Tcm_CD4, Central memory CD4 T cell; Tem_CD4, Effector memory CD4 T cell; Tgd, Gamma delta T cell; Tfh, T follicular helper cell; Th1, Type 1 T helper cell; Th17, Type 17 T helper cell; Th2, Type 2 T helper cell; Treg, Regulatory T cell; MDSC, Myeloid derived suppressor cell; Act_B, Activated B cell; Imm_B, Immature B cell; Mem_B, Memory B cell; NK, Natural killer cell; CD56brigh, CD56bright natural killer cell; CD56dim, CD56dim natural killer cell; NKT, Natural killer T cell; Act_DC, Activated dendritic cell; iDC, Immature dendritic cell; pDC, Plasmacytoid dendritic cell; Mast, Mast cell.