Research Paper Volume 13, Issue 24 pp 25920—25930

LDH-A inhibitors as remedies to enhance the anticancer effects of PARP inhibitors in ovarian cancer cells


Figure 2. LDH-A were increased in SKOV3 with PARP inhibitors treatment. (A, B) Heat map demonstrated the differential genes in the RNA sequencing after PARP inhibitors treated for 24 hours. (C) Venn digram showed the intersection of differential genes in olaparib and AG14361 treated cells. (DG) LDH-A levels in A2780 and SKOV3 were tested by RT-PCR after olaparib or AG14361 treated for 24 hours. Mean ± SEM, ****P < 0.001, ns: no significance.