Research Paper Volume 13, Issue 24 pp 25931—25943

NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway


Figure 5. Expression of p-PI3K, p-AKT, p-mTOR, P62, Beclin1, LC-3A/B and SIRT1 in tissues. (A) Western blotting showed that expressions of p-PI3K, p-Akt and p-mTOR were the highest in the EAE group at the level of tissues. (B) P62, Beclin1, LC-3b and SIRT1 were the up-regulated in the NAD+ group, followed by the NAD+ + SIRT-IN-3 group, the EAE group and the control group at the level of tissues by western blotting.