Research Paper Volume 13, Issue 24 pp 26003—26021

Network pharmacology reveals the potential mechanism of Baiying Qinghou decoction in treating laryngeal squamous cell carcinoma


Figure 5. Survival analysis of key target genes of Baiying Qinghou decoction using a TCGA dataset. The optimal cutoff value of each gene was calculated to stratify all patients into high- and low-expression groups (the left of the AG). Seven genes (ADH1C, EGFR, GSTM1, GSTP1, IL1B, NOS3 and TP53) were significantly associated with the prognosis of HNSCC patients (the right of the AG). The high expression level of ADH1C (A) had a better prognosis of HNSCC patients (P = 0.012). However, the high expression levels of EGFR (B), GSTM1 (C), GSTP1 (D), IL1B (E), NOS3 (F) and TP53 (G) showed the poor prognosis of HNSCC patients. Abbreviations: HNSCC: head and neck squamous cell carcinoma; TCGA: The Cancer Genome Atlas.