Research Paper Volume 13, Issue 24 pp 26022—26033

LINC00839 knockdown restrains the metastatic behavior of nasopharyngeal carcinoma by sponging miR-454-3p


Figure 6. LINC00839 knockdown suppresses tumor growth in vivo. (A) SUNE-1 cells were transected with sh-LINC00839, or miR-454-3p mimic or co-transfected with miR-454-3p mimic and pc-LINC00839, the level was miR-454-3p was assessed by qPCR. (B) SNUE-1 cells were xenogenic transplanted into nude mice (n = 3). Tumor volumes were measured every week and the growth curve of xenograft tumors was drawn. (C) Representative images of xenograft tumors. (D) Tumor weight. (E) Expression levels of miR-454-3p in xenograft tumors were determined by qPCR. (F) Expression level of c-Met in xenograft tumors was determined by western blot. (G, H) Protein levels of E-cadherin and N-cadherin were examined by immunohistochemical staining. **P < 0.01 compared with sh-Ctrl group, ##P < 0.01 compared with miR-454-3p group.