Research Paper Volume 14, Issue 1 pp 297—315

Figure 3. Activation of TIMP-2 in 5-Fu resistant PDX models of CRC in vivo. (A) Schematic presentation of the constructing of a PDX-drug resistance model. (B) Changes in tumor volumes for Veh, 5-FuS and 5-FuR group PDX mice models during the experiment. (C) Differences in TIMP-2 protein levels in Veh, 5-FuS and 5-FuR group PDX mice models. (D) IHC for typical TIMP-2 staining images of subcutaneous tumors formed in Veh, 5-FuS and 5-FuR group PDX mice models. (E) Semi-quantitative IHC staining scores for TIMP-2 as shown in Figure 3C. Data is presented as mean ± SD. Three mice and 6 tumors per experimental group. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 by Student’s t-test or two-way ANOVA.