Research Paper Volume 14, Issue 1 pp 316—329

Deglycosylated EpCAM regulates proliferation by enhancing autophagy of breast cancer cells via PI3K/Akt/mTOR pathway


Figure 5. Effects of EpCAM on the PI3K/AKT/mTOR signaling pathway in MCF-7 and MDA-MB-231 cells. MCF-7 and MDA-MB-231 cells were transfected with pCMV-SPORT 6-EpCAM plasmid, si-EpCAM sequence and M-EpCAM plasmid for 48 hr, respectively. Expressions of pAkt and Akt were detected with method of Western blot.