Research Paper Volume 13, Issue 24 pp 26095—26117

Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors


Figure 2. hsa_circ_0063526 level is higher in EMs ectopic endometrial lesions than control’s eutopic endometrial tissue and hsa_circ_0063526 have binding site with miRNA-141-5p. (A) RT-qPCR analysis of the hsa_circ_0063526 level in the endometriosis group and control group by RT-qPCR. n=41 (*** P<0.005). (B) hsa_circ_0063526 complementary sequence with miR-141-5p. (C) Luciferase reporter experiment showed that miR-141-5p can bind to hsa_circ_0063526 at this site. Replicated 3 times with 3 separate samples (** P<0.01).