NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun

Zigui Chen; Yingying Xie; Hongcheng Luo; Ye Song; Tianshi Que; Rentong Hu; Huatuo Huang; Kunxiang Luo; Chuanyu Li; Chengjian Qin; Chuanhua Zheng; Weiyi Fang; Longyang Liu; Hao Long; Qisheng Luo

doi:doi:10.18632/aging.203805

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Research Paper Volume 13, Issue 24 pp 26180—26200

NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun

Figure 6. Correlation analysis of NAP1L1 and HDGF with overall survival of patients with glioma. (A) Representative immunohistochemistry images and IHC score of expression of NAP1L1 and HDGF in glioma tissues, respectively. Original magnification 400×. (B) Correlation analysis of NAP1L1 and HDGF with overall survival of patients with glioma. Prognostic significance assessed by Kaplan-Meier survival estimates. Comparison of the overall survival by HDGF (C), respectively. (D) Kaplan-Meier analysis of overall survival in patients with variable expression of NAP1L1 and HDGF. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.