Figure 1. Oral administration of Kampo formulas ameliorates depression-like behaviors but not anxiety-like behaviors in SAMP8 mice. The tail suspension test (TST, A), sucrose preference test (SPT, B), and open field test (OFT, C) were performed following treatment with the indicated Kampo formulas or with water for 13 weeks. Data are shown as the mean ± SEM (n = 10−12). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 using Bonferroni’s post-hoc test. Abbreviations: KS: kososan; NKS: nobiletin-rich kososan; HJG: hachimijiogan.