Research Paper Volume 14, Issue 1 pp 225—239

Dietary curcumin restores insulin homeostasis in diet-induced obese aged mice

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Figure 1. Curcumin ameliorates obesity in high-fat high-sugar diet (HFHSD) induced obese aged mice. (A) body weight (g), (B) body weight gain (g), (C) accumulated food intake (g) (n = 7-9). NMR spectrometry was conducted with normal chow diet (NCD), curcumin-supplemented normal control diet (NCD+CUR), high-fat high-sugar diet (HFHSD), and curcumin supplemented high-fat high-sugar diet (HFHSD+CUR) fed mice at baseline, 8 weeks, and 14 weeks of diet (n = 5-9). (D) fat/body weight percentage (%) (E) lean/body weight percentage (%) (F) overall comparison of fat/body weight percentage (%), lean/body weight percentage (%) and fluid/body weight percentage (%) at week 14. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 and ****p ≤ 0.0001.