Research Paper Volume 14, Issue 1 pp 462—476

Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways


Figure 5. Atorvastatin attenuates the effects of LPS on inducing neuroinflammation. Total proteins were extracted from LPS-induced BV2 cells treated with atorvastatin. (A) IL-1β, TNF-α and IL-6; (B) NLRP3 and caspase-1; (C) TLR4 and MyD88 protein expression levels are revealed by western blotting analysis. GAPDH served as an internal control. The band densities were measured by Image J to estimate protein quantities. The results represent the mean ± SD for the repeated experiments. *P < 0.05; **P < 0.01; ***P < 0.001 vs. vehicle treatment. #P < 0.05; ##P < 0.01; ###P < 0.001 vs. LPS treatment.