PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1

Dongsheng Sun; Fujun Li; Lang Liu; Shaobo Yu; Haicun Wang; Xin Gao; Guanglin Liu; Yuqiao Zhao; Gongcai Qiu; Xingming Jiang

doi:doi:10.18632/aging.203828

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Research Paper Volume 14, Issue 1 pp 509—525

PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1

Figure 1. PSMA3-AS1 expression and its association with clinicopathological characteristics. (A) PSMA3-AS1 expression in TCGA database. (B) PSMA3-AS1 expression in CCA tissues and paired adjacent tumor-free bile duct tissues. (C) PSMA3-AS1 expression in CCA cells. (D) Kaplan-Meier curves analyzed the survival correlation. (E) Pearson correlation analysis examined the linear correlation of PSMA3-AS1 expression and survival time. (F) ROC curve assessed the potential of PSMA3-AS1 as a prognostic marker. ^**P < 0.01, ^***P < 0.001.