Research Paper Volume 14, Issue 1 pp 509—525

PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1


Figure 5. miR-376a-3p represses CCA cell proliferation, invasion and EMT. (A) CCK-8 and (B) EdU assays determined the effect of miR-376a-3p on CCA proliferation. (C) Colony formation assay determined the effect of miR-376a-3p on colony-forming ability of CCA cells. (D) Wound healing and (E, F) transwell assays validated the effects of miR-376a-3p on migration and invasion of CCA cells. (G) The effect of miR-376a-3p on EMT process of CCA cells. *P < 0.05, **P < 0.01, ***P < 0.001.