Figure 2. DHA reduces the inflammatory response in the lungs and serum of bleomycin-exposed rats. (A) Il1b, (B) Il6, (C) Tnfa, and (D) Ccl3 mRNA levels in lung tissues were determined to assess the lung inflammatory response (n = 6), data were expressed as the fold change in mRNA expression normalized to Gapdh expression, with respect to the control group. (E) IL-1β, (F) IL-6, (G) TNFα, and (H) CCL3 protein levels in blood were determined to assess the lung inflammatory response (n = 6). *P < 0.05, **P < 0.001. Abbreviations: BLM: bleomycin; DHA-1: dihydroartemisinin 25 mg/kg/d; DHA-2: dihydroartemisinin 50 mg/kg/d; DHA-3: dihydroartemisinin 100 mg/kg/d; NS: not statistically significant; qRT-PCR: quantitative real-time reverse transcription PCR.