COVID-19 Research Paper Volume 14, Issue 3 pp 1110—1127

Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling


Figure 5. DHA reduces bleomycin-induced pulmonary fibrosis in rats. Rats were sacrificed at 28 days after the injection of bleomycin, with or without DHA treatment. Their blood and lungs were removed. (A) H&E staining of bleomycin-treated rat lungs, with and without DHA treatment. (B) Lung inflammation was scored (n = 6). (C) IL-1β, (D) IL-6, (E) TNFα, and (F) CCL3 protein in serum were determined using ELISA (n = 6). Data are expressed as the means ± standard error. *P < 0.05, **P < 0.001. Abbreviations: BLM: bleomycin; DHA-1: dihydroartemisinin 25 mg/kg/d; DHA-2: dihydroartemisinin 50 mg/kg/d; DHA-3: dihydroartemisinin 100 mg/kg/d; NS: not statistically significant; H&E: hematoxylin and eosin; ELISA: enzyme-linked immunosorbent assay.