COVID-19 Research Paper Volume 14, Issue 3 pp 1110—1127

Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling


Figure 7. DHA inhibited pulmonary fibrosis via the JAK2/STAT3 pathway (A) Representative images of (A) TGF-β1, (B) JAK2, and (C) p-JAK2 proteins in lung tissues, detected using IHC. Mean IOD of (D) TGF-β1, (E) JAK2, and (F) p-JAK2 IHC staining. Data are expressed as the means ± standard error. *P < 0.05, **P < 0.001. Abbreviations: BLM: bleomycin; DHA-1: dihydroartemisinin 25 mg/kg/d; DHA-2: dihydroartemisinin 50 mg/kg/d; DHA-3: dihydroartemisinin 100 mg/kg/d; IHC: immunohistochemistry; IOD: integrated optical density; NS: not statistically significant.