COVID-19 Research Paper Volume 14, Issue 3 pp 1110—1127

Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling


Figure 8. (A) STAT3, and (B) p-STAT3 protein in lung tissues, detected using IHC. Mean IOD of (C) STAT3, and (D) p-STAT3 IHC staining. Data are expressed as the means ± standard error. (E) and (F) Western blotting analysis of TGF-β1, JAK2, p-JAK2, STAT3, and p-STAT3 proteins in lung tissues. (All n = 6). *P < 0.05, **P < 0.001. Abbreviations: BLM: bleomycin; DHA-1: dihydroartemisinin 25 mg/kg/d; DHA-2: dihydroartemisinin 50 mg/kg/d; DHA-3: dihydroartemisinin 100 mg/kg/d; IHC: immunohistochemistry; IOD: integrated optical density; NS: not statistically significant.