Research Paper Volume 14, Issue 3 pp 1351—1373

Identification and external validation of the hub genes associated with cardiorenal syndrome through time-series and network analyses


Figure 5. The diagnostic ability of FN1 and POSTN to CRS. (A, B) FN1 (A) and POSTN (B) were up-regulated in the peripheral blood sample of CRS patients from the Shunde Hospital of Southern Medical University. (C) The ROC analysis showed that FN1 and POSTN could discriminate the CRS samples with high efficacy. (DH) The association of FN1 expression with LVEF (D), NTproBNP (E), Scr (F), BUN (G), and UA (H). (IM) The association of POSTN expression with LVEF (I), BUN (J), Scr (K), NTproBNP (L), and UA (M). Abbreviations: CRS: cardiorenal syndrome; ROC: receiver operating curve; LVEF: left ventricular ejection fraction; NTproBNP: N-terminal-pro-B-type natriuretic peptide; Scr: serum creatinine; BUN: blood urea nitrogen; UA: uric acid. *P < 0.05; **P < 0.01; ***P < 0.001.