**Figure 4.** **Evaluate the independent prognostic value of the risk score by using the Cox regression analysis.** The (**A**) univariate cox regression and (**B**) multivariate cox regression analysis of age, gender, grade, and risk score. Calculate the AUC for age, gender, grade, and risk score of the total survival according to the multivariate time-dependent ROC curve for 1-year (**C**), 3-years (**D**) and 5-years (**E**).