Research Paper Volume 14, Issue 3 pp 1214—1232

Ribosomal DNA methylation in human and mouse oocytes increases with age


Figure 4. Methylation variation of multiple oocytes from the same woman. Methylation variation of the rDNA UCE (upper panel) and core promoter (lower panel) in individual (color-coded) oocytes from the same woman. Women 1-42 are arranged with increasing age (from 26 to 39 years) on the x-axis. Most women, i.e. numbers 3 and 23 show similar methylation values in different oocytes and rDNA amplicons. Some women, i.e. 12 and 21 display enormous methylation variation between oocytes.