Figure 4. Methylation variation of multiple oocytes from the same woman. Methylation variation of the rDNA UCE (upper panel) and core promoter (lower panel) in individual (color-coded) oocytes from the same woman. Women 1-42 are arranged with increasing age (from 26 to 39 years) on the x-axis. Most women, i.e. numbers 3 and 23 show similar methylation values in different oocytes and rDNA amplicons. Some women, i.e. 12 and 21 display enormous methylation variation between oocytes.