Research Paper Volume 14, Issue 4 pp 1729—1742

The elevation of miR-185-5p alleviates high-fat diet-induced atherosclerosis and lipid accumulation in vivo and in vitro via SREBP2 activation


Figure 2. MiR-185-5p mimic decreased atherosclerotic lesions in HFD-fed apoE−/− mice. To induce atherosclerosis, apoE−/− mice fed a high-fat diet were administered with miR-185-5p mimic via tail vein once every 2 weeks for 12 weeks. (A) hepatic cholesterol levels and serum cholesterol levels, (B) The descending arteries were obtained from the apoE−/− mice and stained with Oil-red-O to examine the plaque formation. (C) The longitudinal section of the mice's aortic root was stained with Oil red O to examine the lesion area.