Research Paper Volume 14, Issue 4 pp 1865—1878
miR-223-3p inhibits the progression of atherosclerosis via down-regulating the activation of MEK1/ERK1/2 in macrophages
Figure 5. MiR-223-3p mimics inhibits the inflammatory response was via the ERK1/2 pathway in vitro. (A) The western blots analysis revealed that p-ERK1/2, IL6, and TNF-a were significantly suppressed in miR-223-3p mimic-transfected macrophages with ox-LDL stimulation, and the decreased expression levels of p-ERK1/2, IL6, and TNF-a were markedly enhanced in miR-223-3p mimic-transfected macrophages with ox-LDL by C16-PAF. (B) The quantitative analysis revealed that the relative protein levels of p-ERK1/2, IL6, and TNF-a were decreased in miR-223-3p mimic-transfected macrophages with ox-LDL stimulation, and the decreased relative protein levels of p-ERK1/2, IL6, and TNF-a were markedly enhanced in miR-223-3p mimic-transfected macrophages with ox-LDL by C16-PAF. (*P<0.05).