Research Paper Volume 14, Issue 4 pp 1983—2003

Pseudogene AK4P1 promotes pancreatic ductal adenocarcinoma progression through relieving miR-375-mediated YAP1 degradation


Figure 8. The ceRNA mechanism of pseudogene AK4P1 promotes PDAC progression. Genomic DNA sequence of pseudogene AK4P1 was similar to parent gene AK4. Where oncogene YAP1 is targeted by the miR375-guided RNA-induced silencing complex (miR375-RISC), leading to accelerate YAP1 degradation. And when the pseudogene-derived lncRNA is transcribed and exported to the cytoplasm, it competes for miRNA targeting and binding of RISC complexes, leading to relieve miR-375-mediated YAP1 degradation and increase YAP1 expression, which can promote PDAC progression. Abbreviations: AGO: Argonaute; RNAP II: RNA polymerase II.