Figure 1. Cisd2 attenuates liver aging and preserves a young-like proteome and transcriptome. (A) An age-dependent decrease in Cisd2 correlates with extensive molecular, cellular and pathological alterations within the liver. Whole-body Cisd2 overexpression (Cisd2TG) attenuates aging-induced liver injury and related molecular changes, as evidenced by histopathological and 'omics analyses. (B) A Western diet accelerates progression of non-alcoholic fatty liver disease (NAFLD) phenotypes, namely hepatic steatosis, inflammation and fibrosis. Maintaining a high-level of Cisd2 by exercise or by the introduction of compounds that activate Cisd2 expression should protect the liver from age-related pathological changes. Figure created with BioRender.com.