Research Paper Volume 14, Issue 5 pp 2174—2193

Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis


Figure 2. Guinea pigs (Cavia porcellus) with TB exhibited systems-levels similarity with humans with TB. (A) Venn diagrams depicting the overlap between genes with DNA hypermethylation in guinea pig spleen (blue circle), lungs (pink circle) and humans with TB (CD4, yellow circle; CD8, blue circle; CD14, green circle). The p-value of overlap are shown on the side for ‘S’: Spleen; ’L”: Lung. (B) Pathway enrichment analysis (MsigDB GSEA) demonstrating overlap in hypermethylated pathways in humans (light grey bars) and guinea pigs (dark grey bars) with TB. The box colors demonstrate –log 10 p-value of enrichment, with darker shades of blue indicating significance, with the −log10 p-values written in the square. Selected TB-relevant pathways are depicted.