Research Paper Volume 14, Issue 5 pp 2194—2209

Tonsil mesenchymal stem cells-derived extracellular vesicles prevent submandibular gland dysfunction in ovariectomized rats


Figure 4. Anti-inflammatory effect of T-MSCs-derived extracellular vesicles. Quantitative polymerase chain reaction analysis of tumor necrosis factor alpha (TNF-α), interferon γ, interleukin 1β (IL-1 β), and interleukin 6 (IL-6) in the submandibular gland. The mRNA expression of TNF-α, IL-1, and IL-6 was higher in the OVX group than in the SHAM group. Extracellular vesicles treatment decreased the TNF-α and IL-6 levels. One-way ANOVA test; *p < 0.05 and **p < 0.01 vs. SHAM, #p < 0.05 vs. OVX.