Research Paper Volume 14, Issue 5 pp 2194—2209

Tonsil mesenchymal stem cells-derived extracellular vesicles prevent submandibular gland dysfunction in ovariectomized rats


Figure 6. Increased salivary gland function by injected T-MSCs-derived extracellular vesicles. The AQP5- and α-amylase-positive areas significantly decreased in the OVX groups compared with those in the SHAM group. However, AQP5 and α-amylase expression increased in the OVX+EV treatment group (A and B). The mRNA expression of AQP3 and AQP5 decreased in the OVX group and increased mRNA expression of AQP3 and AQP5 in the OVX+EV treatment group, compared with that in the SHAM group (C). One-way ANOVA test; and *p < 0.05 and ***p < 0.001 vs. SHAM, #p < 0.05 and ##p < 0.01 vs. OVX.