Research Paper Volume 14, Issue 5 pp 2400—2417

Manual therapy regulates oxidative stress in aging rat lumbar intervertebral discs through the SIRT1/FOXO1 pathway


Figure 1. Effects of MT on the behaviors of aging rats. (A) The PWT of rats were obtained by stimulating to assess their mechanical hyperalgesia. Compared with the previous time point of this group, #P < 0.05, ##P < 0.01; compared with the AG at the same time point, *P < 0.05, **P < 0.01. Rats in the YCG were 6 months old at BL; rats in the AG and MTG were 12 months old at BL. (B) The open field test was used to measure mobility and voluntary standing to indirectly reflect whether the rats had LBP. (CF) Further quantitative analysis was used for the distance traveled, mean and max speed, and the standing time/ resting time of the rats. Values are expressed as the mean ±SD (N = 8). Compared with the YCG, ##P < 0.01; compared with the AG, *P < 0.05, **P < 0.01. PWT: paw withdrawal threshold, BL: baseline, YCG: young control group, AG: aging group, MTG: manual therapy group.