Research Paper Volume 14, Issue 6 pp 2590—2606

The TLR4/NF-κB/MAGI-2 signaling pathway mediates postoperative delirium

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Figure 7. Postoperative behavior test in aged mice. Buried food test (A): the latency time to eat food was longer in AS and ASP groups than in C group at 6 h after surgery; the latency time of to eat food was shorter in ASP group at 6 h after surgery compared with AS group; and the latency time to eat food was longer in AS and ASP groups at 9 h after surgery compared with C group. Y-maze test (BD): The total number, percentage of duration, and number of novel arm visits were decreased in the AS and ASP groups than in the C group at 6 h after surgery; the number of arms visit and number of novel arm visit were increased in the ASP group compared with the AS group. Compared with the C group, the number of arms visits at 9 h postoperatively was decreased in the AS and ASP groups, and the percentage of duration of novel arm visits was lower in the AS group than in the C group; the number of arms visits at 9 h postoperatively was higher in the ASP group than in the AS group. Open field test (EG): the total distance and time spent in the center were shorter in the AS and ASP groups than those in C group and the latency to center was longer than those in C group at 6 h postoperatively. Compared with the AS group, the total distance and time spent in the center in the ASP group were increased and the latency to center was decreased at 6 h postoperatively. Compared with the C group, the time spent in the center was shorter in the AS group at 9 h postoperatively. Compared with the C group, *p<0.05; compared with the AS group, #p<0.05.