Figure 1. Single-cell transcriptomic profiles from colon biopsies from UC patients and healthy individuals. (A) Study design. (B) 2d visualization of 51 clusters of cells in healthy controls (up) and UC patients (down) on the UMAP plot. (C) Violin plots of specific marker genes in all types in healthy individuals. (D) Ridge plot. Expression of marker genes common to healthy individuals (left) and UC patients (right). (E) The heat map showing expression of UC-specific marker genes in healthy individuals (left) and UC patients (right). UMAP: uniform manifold approximation and projection for dimension reduction. UC: ulcerative colitis.