Review Volume 14, Issue 6 pp 2902—2919

Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment


Figure 1. Schematic representation of mitochondrial fusion and fission process and mitophagy in pancreatic β cells. Under the condition of hyperglycaemia, oxidative stress triggered the damaged mitochondria. Mitophagy was activated to remove damaged mitochondria by encapsulation of autophagosome. Afterwards, autophagosome fused with lysosome and formed autolysosome to degrade the damaged mitochondria via acidic lysosomal hydrolase.