Research Paper Volume 14, Issue 6 pp 2775—2792

Construction and evaluation of a nomogram for predicting survival in patients with lung cancer


Figure 8. Working model of major enrichment pathways in lung cancer. Proteins activated by CDC7, DBF4, CYCE, MCM, and CDC6 promote DNA replication, in addition to promoting cell amplification, particularly transcription factor E2F, which is regulated by numerous genes. In addition, upregulation of the transcription activity of E2F promotes Skp2 regulation of the PI3K/AKT pathway, thereby potentially promoting the occurrence of lung cancer.