Research Paper Volume 14, Issue 7 pp 2945—2965

E-cadherin deficiency promotes prostate macrophage inflammation and bladder overactivity in aged male mice

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Figure 4. Impact of E-cadherin-deficiency on macrophage density in the murine prostate at 24 months of age. (A) Quantification of CD68+ macrophages in the prostate from Control and Cdh1+/- mice at 24 months of age. Abbreviations: vp: ventral prostate; lp: lateral prostate; dp: dorsal prostate; ap: anterior prostate. Data represent mean ± S.D, number of mice in each group in parentheses. Lobes which had been washed away during staining process were not quantified. (B) CD68 immunostaining (brown) in transverse sections of prostate ventral, lateral, dorsal, and anterior lobes from Control and Cdh1+/- mice at 24 months of age. Lobes which had been washed away during staining process were not quantified. Original magnification, 40×, inset 40×. *p < 0.05, **p < 0.01. Scale bars indicate 50 μm in 40×.